FOXF2 mRNA expression negatively correlates with the size of NSCLC, and patients with high-expressing FOXF2 mRNA have significantly better survival than patients with low-expressing FOXF2. FOXF2 may inhibit growth and metastasis of cancer cells by regulating ECM remodeling and EMT process or other mechanisms. The gene discussed is FOXF2; the disease is non-small cell lung carcinoma.