To obtain the evidence supporting a role for YMO1 (EPB41L5) in the recurrence and metastasis of HCC, we first examined its expression in HCC tissue and the adjacent nontumoral liver tissue (ANLT) in the same patient by real-time PCR, in which 30 HCC patients were randomly selected for the study. Here, EPB41L5 is linked to hepatocellular carcinoma.