According to our results of genomic bisulfite sequencing, KDM4B, rather than DNMT1, DNMT3a, KDM4A, KDM4C, KDM5A or KDM6A, had a significant effect on the demethylation of the miR-615-5p promoter in HCC cells. This evidence concerns the gene KDM4C and hepatocellular carcinoma.