IGF1R and neoplasm: Because little is known about the complex interaction between the tumor cell and its surrounding environment[26], the purpose of this study was to evaluate (1) the effect of pancreas fibroblasts on the invasive activity of PDAC cells under hypoxia; and (2) the therapeutic efficacy of IGF1R signaling inhibitor against invasion by PDAC with regard to the tumor–stromal interaction under hypoxia.