In a study comparing high-volume hemofiltration (6 L/hour) with standard continuous hemofiltration (1 L/hour) in patients with septic shock and multiple organ failure, the former was associated with a greater (temporary) decrease in vasopressor requirements and both therapies were associated with a temporary reduction in serum concentrations of the complements C3a and C5a [24]. The gene discussed is C3; the disease is septic shock.