PRAME and melanoma: Similarly, PRAME+ status was associated with shorter time to melanoma-specific mortality for both Class 1 and Class 2 tumors together (P = 0.001; 32 melanoma-specific mortality events; median follow-up of 19 months, range 0–142 months) and for Class 2 tumors alone (P = 0.02; 28 melanoma-specific mortality events, median follow-up of 18 months, range 0–89 months) (Figure 3C–3D).