CASP3 and neoplasm: According to the tumor suppressive functions of TAp73 [28], the consequent 50% reduction of TAp73β's expression obtained in the RDES cell line (Figure 3a) leads to a significant diminution of its caspase 3/7 activity, supporting the implication of the TAp73β isoform in the apoptotic processes in these cells (Figure 3b).