In addition, Singer et al. showed that patients with heart failure had lower TTR mean levels (52.9±21.2 vs 59.0±20.7 p < 0.001) [9] and Rose et al. found that heart failure was associated with poor control (TTR < 60% = 26.1% vs TTR > 75% = 20.5% p < 0.001) [26]. This evidence concerns the gene TTR and heart failure.