Moreover it has been shown that a small proportion of pancreatic tumors arises as a result of high penetrance germline mutations in genes such as BRCA1, BRCA2, p16/CDKN2A, STK11/LKB, ATM, PALB2, and DNA mismatch repair genes, usually in the context of familial cancer syndromes [2, 3, 11–15]. The gene discussed is CDKN2A; the disease is pancreatic neoplasm.