Activation of the liver kinase B1 (LKB1)-5′ adenosine monophosphate-activated protein kinase (AMPK) pathways by metformin may inhibit the growth of cervical cancer cell lines, through blocking the mammalian target of rapamycin (mTOR) [23], the Wnt/β-catenin [24] and the Forkhead Box M1 (FOXM1) [25] signaling cascades. The gene discussed is FOXM1; the disease is cervical cancer.