CD38 and B-cell chronic lymphocytic leukemia: A multivariate Cox's analysis of known poor prognostic CLL features (IGHV status, LDT, CD38, Binet stage) showed that unmutated IGVH genes significantly and independently predicted PFS in this patient subgroup with the hazard ratio of 2.2 (95% CI: 1.0 to 4.3, P= 0.022).