As expected, we found that Cdc42 co-localized with filopodia in glioma cells, and Cdc42 knockdown with siRNA decreased filopodia formation and induced a change in shape towards polygonal (A172 and U87MG), or more rounded (U118MG) morphologies, accompanied by a reduction in actin stress fibers (Figure 1B). This evidence concerns the gene CDC42 and central nervous system cancer.