We found that both miR483 and miR483-5p upregulated the expression of the endogenous IGF2. In both tumor cell lines (ASPC, HCT116), we detected a  ̃9-fold increase in IGF2 mRNA transcripts in miRNA-transfected cells over that in the vector-control cells (Figure 3C). This evidence concerns the gene IGF2 and neoplasm.