We and others have previously shown that dietary pomegranate supplementation can attenuate chronic oxidative stress in APPsw/Tg 2576 mice, reduce acetylcholinesterase activity and plasma Aβ1-40 and Aβ1-42 levels, and ameliorate memory and anxiety-related behavioural deficits, and improve spatial learning ability in vivo, consistent with our findings [47-49]. The gene discussed is ACHE; the disease is Anxiety.