AKT1 and Alzheimer disease: The current study explores the effect of pomegranate supplementation on stress in the brain, synaptic plasticity, neuroinflammation, and Aβ production in the AD transgenic mice, and examines potential disease-related modifications to the expression of synaptic plasticity-related proteins, activation of the PI3K/Akt/mTOR pathway, neuroinflammation, and altered amyloidogenic processing.