SMO and chronic myelogenous leukemia, BCR-ABL1 positive: In mice, loss of function of the seven-transmembrane domain protein Smoothened (Smo), a key component of the Hedgehog (Hh) signaling pathway, affects renewal of the hematopoietic stem cell (HSC) and inhibits LSC expansion reducing the transplantability of the disease in a CML murine model.