mRNA levels of the Wnt target gene AXIN2 [30] were analyzed by qPCR in blasts from 40 AML patients with normal karyotype (30 with NPM mutations and 10 without) and in normal hematopoietic cells (CD34+ progenitors, monocytes and granulocytes, Figure 7). The gene discussed is CD34; the disease is acute myeloid leukemia.