Nevertheless, studies involving tumors of several organs have suggested that high expression of the prolymphangiogenic factor vascular endothelial growth factor-C (VEGF-C) and high intratumoral or peritumoral lymph vessel density (LVD) are correlated with lymph node metastasis and poor prognosis [10, 13, 14]. Here, VEGFC is linked to metastatic malignant neoplasm in the lymph nodes.