AKT1 and cancer: The majority of drugs that exhibited significant differences (P < 0.05) in sensitivity between ARID1A-mutant and ARID1A-wildtype cancer cell lines were enriched in 1) inhibitors of the PI3K/AKT pathway (AZD8055, NVP-BEZ235, MK-2206, and GDC-0941) or 2) agents that induce DNA damage or inhibit the DNA damage response (cisplatin, KU-55933, and NU-7441) (Table 1).