In the recent years, quite a few of SNPs at the TOX3/LOC643714 locus including rs3803662, rs3104746, rs8051542, rs4784227, rs12443621, rs3112612, rs3112562, rs3104793, rs8046994, rs3104788, and rs3104767, were demonstrated to be independently associated with elevated risk of breast cancer and the other human diseases [16–43]. The gene discussed is TOX3; the disease is breast carcinoma.