SMARCA4 and neoplasm: To further delineate if BRG1 might be silenced by mutations, we downloaded and compiled the mutational data for various tumors and specifically examined the frequency of silent and missense mutations (which typically do not abrogate or disrupt gene expression), nonsense mutations and insertion/deletions (which typically abrogate gene expression), and total mutations for 13 tumor types from the COSMIC database and 23 tumor types from the Atlas database.