Mouse studies from Dr. J. Aronowski and colleagues suggested that Hp is expressed and secreted by brain oligodendrocytes after experimental intracerebral hemorrhage and that brain-derived Hp plays a significant role in the protection of brain cells after injury (Zhao et al., 2009, 2011) in addition, a rat study by Dr. Kim and colleagues suggested Hp expression in the hippocampus following brain ischemia (Lee et al., 2002). The gene discussed is HP; the disease is brain ischemia.