Our previous study has shown that AIB1 is a bonafide oncogene that is overexpressed in human HCC specimens and promotes HCC progression by enhancing cell proliferation and invasion, and AIB1 knockdown leads to p-Akt down regulation, p21Cip1/Waf1 up-regulation and cell cycle arrest in HepG2 cells [26]. Here, CDKN1A is linked to hepatocellular carcinoma.