Furthermore, the expression of Th2 cytokines IL-10 and IL-13 and Th2 chemokine CCL22 were significantly decreased in symptomatic compared with asymptomatic plaques (by 3.2-fold, p < 0.05; 8.9-fold, p < 0.05, and 4.8-fold, p < 0.01, respectively) and again there was a trend toward decreased IL-4 and CCL18 expression (Table 3; Figure 4), suggesting a decrease in MΦ2 macrophages in the progression of human atherosclerosis. The gene discussed is CCL22; the disease is atherosclerosis.