THBS1 and vascular disorder: These data support a mechanism of disease pathogenesis characterized by decreased expression of THBS1 in infected endothelial cells, which in turn leads to a perturbation of normal vascular integrity, and possibly hemostasis, which ultimately contribute to the severe vascular disorders characteristic of pathogenic hantavirus pathology (Adams, 1997; Sargianou et al., 2012; Manigold and Vial, 2014).