Secretion of THBS1 by endothelial cells can be modulated by proinflammatory cytokines such as TNFα and IL-1, two cytokines that are commonly observed in association with hantavirus infection (McPherson et al., 1981; Lawler and Detmar, 2004; Lopez-Dee et al., 2011). This evidence concerns the gene TNF and hantavirus infectious disease.