Based on the strong association of the presence of HLA-B*58:01 and DRESS and SJS-TEN, it is presumed that the attributable risk of CADR due to the existence of this allele is larger—as high as 8% in Thailand (Puangpetch et al., 2015)—indicating that HLA-B*58:01 is associated with the pathogenesis of allopurinol-induced CADR regardless of the phenotype or severity. The gene discussed is HLA-B; the disease is toxic epidermal necrolysis.