RUNX2 and Familial prostate cancer: In prostate cancer, FOXO1 inactivation due to frequent loss of phosphatase and tensin homolog (PTEN) in prostate cancer cells may render the oncogenic activities of runt-related transcription factor 2 (Runx2) unchecked, thereby driving promiscuous expression of Runx2 target genes involved in cell migration and invasion and favoring prostate cancer progression [24].