ACHE and neurodegenerative disease: Hence the present study sought to investigate the effect of the salt substitutes (Obu-Otoyo), salt A and salt B, on some key enzymes linked with neurodegenerative disease [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities] as well as on the malondialdehyde (MDA) content of rat brain in vitro in order to provide some evidence for the neurotoxic effect of these salt substitutes.