SORCS2 and early-onset autosomal dominant Alzheimer disease: SORCS2 is a type I trans-membrane glycoprotein receptor that belongs to the mammalian Vps10p family21, they plays a key role in brain disease, such as attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BPD), schizophrenia and Alzheimer disease (AD)22, 23, 24, 25.