On day 11, the tumor size in siPRDM5 group was significantly smaller than in siCTL group (Fig. 3A and B) and the tumor weight in siPRDM5 group was also significantly lighter than in siCTL group (Fig. 3C), indicating that PRDM5 silencing inhibits the growth of melanoma cells in vivo. This evidence concerns the gene PRDM5 and neoplasm.