HTR5A and Anxiety: Because the excitability of BLA principal cells, which presumably represents a functional basis of anxiety states, is potently controlled by local GABAergic interneurons (Rainnie et al. 1991; Washburn and Moises 1992; Lang and Paré 1997, 1998), the regulation of GABAergic synapses by 5-HT is in line with a potential role of 5-HT signaling in the BLA in anxiety-related behaviors (Strauss et al. 2013; Vicente and Zangrossi 2014).