Several lncRNAs are involved in the carcinogenesis, disease progression, or metastasis of human cancers (e.g., MALAT1 in hepatocellular carcinoma, colorectal carcinoma, bladder cancer, and lung cancer; HOTAIR in breast cancer, hepatocellular carcinoma, pancreatic cancer, gastric cancer, laryngeal cancer, and nasopharyngeal cancer; H19 in cervical, gastric, bladder, breast, esophageal, and lung cancer; PCGEM1 in prostate cancer) [10]. This evidence concerns the gene HOTAIR and lung cancer.