Compared with kidney tissue sections from patients with nephritic syndrome and normal kidney tissue (para-carcinoma tissue of kidney cancer), a massive agIgA1 deposition in glomeruli of patient kidney biopsy with IgAN was detected by immunofluorescence with anti-human IgA1 antibody and HAA binding (Fig. 4A,B). This evidence concerns the gene IGHA1 and carcinoma.