This suggests that TSH release of the pituitary in response to TRH stimulation might be an important factor contributing to the frequently found high normal baseline serum TSH concentrations in children with overweight and obesity (Fig. 3), which is associated with several obesity related complications1, 2, 3, 4, 5, 6, 7. This evidence concerns the gene TRH and obesity due to melanocortin 4 receptor deficiency.