PSEN1 and Cognitive impairment: This widely used AD model [Tg(Thy1‐APPSw, Thy1‐PSEN1*L166P) 21Jckr] typically shows amyloid deposition in the hippocampus at 3–4 months and cognitive impairment at 7–8 months of age (Radde et al, 2006; Serneels et al, 2009).