We demonstrate here that downregulation of miR‐132 aggravates both amyloid and TAU pathology in AD mice and that it regulates the expression of inositol 1,4,5‐trisphosphate 3‐kinase B (ITPKB), a regulator of BACE1 activity and TAU phosphorylation (Stygelbout et al, 2014). This evidence concerns the gene BACE1 and Alzheimer disease.