Our results indicate that: (1) viral sequences in residual viremia are predominantly related to proviral sequences in effector and transitional memory CD4+ T-cells suggesting that residual viremia originates from these cells, and (2) there is limited sequence relationship between episomal vDNA and plasma viral RNA, suggesting that viruses in plasma are not the source of the de novo infection events detected in peripheral CD4+ T-cells. Here, CD4 is linked to infection.