That similar responsiveness of CD8+ T cells specific to tumor antigens was observed after individual in vitro stimulation with four different tumor epitopes only in samples obtained after anti-TTx and was not evident in cells before anti-TTx (Fig. 4d left panels), lead us to argue that the anti-TTx in this patient efficiently promotes the responsiveness of tumor specific effector CD8+ T cells (TEMRA). The gene discussed is CD8A; the disease is neoplasm.