To assess changes in the repertoire of TAA specific CD8+ T cells in peripheral blood induced by anti-TTx and their relationship with tumor infiltrating lymphocytes, we compared to ex vivo by FC the TCR-Vβ repertoire of HER2/neu369–377 tetramer positive CD8+ T cells present in PBMCs from the patient before and after anti-TTx. This evidence concerns the gene CD8A and neoplasm.