CD4 and HIV infectious disease: It is interesting to observe that, at early infection, we have seen variable expression of IL-17 coinciding with lower levels of ANXA1, and these results are corroborated by minimal CD4+ Th17 dysregulation in the blood until later stage of HIV infection, while gastrointestinal Th17 depletion was apparent much earlier, along with increased plasma markers of microbial translocation58.