In addition, Esteller and the associates used methylation array to establish methylation profiles of stage I Caucasian non-small cell lung cancer and identified that methylation of two or more genes in HIST1H4F, PCDHGB6, NPBWR1, ALX1, and HOXA9 correlated with an increased risk of cancer recurrence [16]. The gene discussed is NPBWR1; the disease is cancer.