We also observed that the miR-141/200c cluster significantly increased the phosphorylation levels of FAK (1.98 ± 0.37-fold, p = 0.04) and AKT (5.61 ± 1.73-fold, p = 0.04) in HCC-38 cells (Additional file 6: Figure S6C, D). Here, PTK2 is linked to hepatocellular carcinoma.