To test if DM1 specific splice errors contribute to the development of these phenotypes, we studied the splice patterns of twenty RNAs including the Insulin Receptor (Insr), Lim Binding Domain 3 (Ldb3) and Cardiac Troponin T (Tnnt2) RNAs in Mbnl3ΔE2 mice. The gene discussed is LDB3; the disease is myotonic dystrophy type 1.