Also opposite to the results obtained in TRs KO mice, hyperthyroidism resulted in increased hepatic levels of IL-6 and SOCS3 transcripts in response to 5 mg/kg LPS (Fig. 4A) or 20 mg/kg LPS (Fig. 4B), while TNFα and IL-10 mRNAs remained unchanged. The gene discussed is IL10; the disease is hyperthyroidism.