Although the tumor suppressor PTEN, a lipid phosphatase acting in direct enzymatic opposition to PI3K, is infrequently inactivated by mutations in sporadic BC (5 %), PTEN protein expression is significantly reduced in ~25 % breast tumors, more commonly in ER-negative cancer and in particular within BLBC, and rarely coinciding with PIK3CA mutation [2, 7]. The gene discussed is PIK3CA; the disease is breast cancer.