Interestingly, only PVT1 was found to be decreased in ASMCs from patients with nonsevere asthma and increased in ASMCs from patients with severe asthma, and therefore we performed functional studies on this lncRNA in our model of asthmatic hyperproliferation and corticosteroid insensitivity.3, 5 The action of PVT1 in our ASMCs from asthmatic patients was complex. Here, PVT1 is linked to asthma.