ADRA2B and laryngotracheoesophageal cleft: The present study in an experimental model of obstructive LC shows an increase in EFS-induced vasoconstriction in superior mesenteric artery that is the net effect of 1) increased sensitivity to NA through enhanced alpha 2B adrenoceptor expression and ROCK activity, and augmented ATP release, and 2) elevated neuronal NO and CGRP releases from the nitrergic and sensory innervations, respectively.