Bcl-2 family proteins were shown to regulate the MMP during apoptosis, and data in Fig 3B show that EVO altered expressions of antiapoptotic Bcl-2 family proteins including the Bcl-2 and Mcl-1 proteins, and the proapoptotic Bcl-2 family protein, Bax, in A498 RCC cells. The gene discussed is BAX; the disease is renal cell carcinoma.