In human A498 RCC cells, EVO stimulation induced JNK protein phosphorylation and Bcl-2 protein phosphorylation at Ser-70, and suppression of JNK protein phosphorylation by JNK inhibitors significantly protected A498 cells from EVO-induced apoptosis, along with decreased Bcl-2 protein phosphorylation. The gene discussed is BCL2; the disease is renal cell carcinoma.