In subgroup analyses, patients with lower SIRT3 expression correlate with poor differentiation as compared with those with higher SIRT3 expression in hepatocellular carcinoma (OR = 0.69, 95% CI = 0.48–0.98, P = 0.04) and gastric cancer (OR = 0.33, 95% CI = 0.21–0.50, P<0.00001). Here, SIRT3 is linked to hepatocellular carcinoma.