Emotional disturbances associated with PSD, such as lack of motivation, depressed mood, agitation and anxiety, are common after stroke.3 Current antidepressant treatments result in remission in only 30% of depressed patients, hence improved preclinical ischemic models are needed to develop and optimize therapies for PSD.26 Herein, we have developed a mouse model of PSD using unilateral microinjection of ET-1 into the left mPFC. The gene discussed is EDN1; the disease is stroke disorder.