Among the interesting cytokines regarding immunotherapy, interleukin-18 (IL-18), a cytokine species in the interleukin-1 family, has exhibited anti-cancer properties, via stimulation of natural killer cells (NK cells)[8] and cytotoxic T lymphocytes[9], as well as showing inhibitory effects on cancer cell growth and metastasis [10]. This evidence concerns the gene IL18 and cancer.