To investigate the effectiveness of PF-06463922 in vivo we orthotopically injected human neuroblastoma cells (CLB-BAR, amplified MYCN/ALK, ALKΔexon 4-11) into the adrenal glands of BalbC/nude mice, prior to treatment with either crizotinib or PF-06463922. This evidence concerns the gene ALK and neuroblastoma.