Expression of both an active ALKF1174L mutation together with MYCN overexpression in mice potentiates the development of neuroblastoma with earlier onset, higher penetrance and enhanced lethality (Berry et al., 2012), which upon treatment with crizotinib shows some degree of growth inhibition compared with vehicle treated mice (Berry et al., 2012). The gene discussed is MYCN; the disease is neuroblastoma.