In parallel we examined the activity of PF-06463922 in conjunction with gain-of-function ALK variants expressed in PC12 cells, which is a clonal rat adrenal pheochromocytoma cell line with enteric cell origin, with the ability to differentiate and extend neurites upon protracted ERK1/2 stimulation (Cowley et al., 1994). This evidence concerns the gene MAPK3 and adrenal gland pheochromocytoma.