Ceritinib (LDK378) (Shaw and Engelman, 2014) was recently approved for use in crizotinib-relapsed ALK fusion-positive NSCLC in the US and Europe, and brigatinib (AP26113) (Katayama et al., 2011) has received a breakthrough therapy designation by the FDA (http://www.fda.gov/downloads/aboutfda/centersoffices/officeofmedicalproductsandtobacco/cder/ucm447165pdf, pp 11-15) (Table 1). This evidence concerns the gene ALK and non-small cell lung carcinoma.