DYRK1A and Alzheimer disease: Because deregulation of calcineurin and nuclear factor of activated T cells (NFAT) signaling is related to the development of a DS- and AD-like phenotype, and because DYRK1A plays an important role in this signaling pathway (Arron et al., 2006), we examined the effect of CX-4945 on NFAT signaling involving DYRK1A by imaging the translocation of Flag-tagged NFATc1.